Rituximab for Treatment of Membranoproliferative Glomerulonephritis and C3 Glomerulopathies

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Rituximab for Treatment of Membranoproliferative Glomerulonephritis and C3 Glomerulopathies

Membranoproliferative glomerulonephritis (MPGN) is a histological pattern of injury resulting from predominantly subendothelial and mesangial deposition of immunoglobulins or complement factors with subsequent inflammation and proliferation particularly of the glomerular basement membrane. Recent classification of MPGN is based on pathogenesis dividing MPGN into immunoglobulin-associated MPGN a...

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Membranoproliferative glomerulonephritis associated with mixed cryoglobulinemia is the most common form of kidney disease observed in relation to hepatitis C virus (HCV) infection. Rituximab, a monoclonal antibody against CD20, is an effective treatment for severe and/or refractory HCV-related vasculitis and may evade the need for dialysis as in our patient.

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Membranoproliferative glomerulonephritis and C3 glomerulopathy: resolving the confusion.

Membranoproliferative glomerulonephritis (MPGN) denotes a general pattern of glomerular injury that is easily recognized by light microscopy. With additional studies, MPGN subgrouping is possible. For example, electron microscopy resolves differences in electron-dense deposition that are classically referred to as MPGN type I (MPGN I), MPGN II, and MPGN III, while immunofluorescence typically d...

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Rituximab Treatment for PR3-ANCA-Positive Membranoproliferative Glomerulonephritis Associated with Adult-Onset Periodic Fever Syndrome

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Monoclonal antibodies for the treatment of the C3 glomerulopathies.

Our understanding of glomerular disease has been steadily progressing from pattern-based histologic classification and empirical immunosuppressive treatments to better molecular characterization of disease and, albeit more slowly, to more targeted therapies. The group of diseases collectively known as membranoproliferative GN (MPGN) has recently been the beneficiary of such a step forward (for ...

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ژورنال

عنوان ژورنال: BioMed Research International

سال: 2017

ISSN: 2314-6133,2314-6141

DOI: 10.1155/2017/2180508